Course overview
The aims of the course will be to introduce and expand on fundamental process and technological tools for the upstream and bioformulation of biopharmaceutical production processes. This course will include topics on cell line development, media development, production parameters and fermenter design, scale-up and technology transfer, harvesting and extraction, formulation development, product complexity and analysis. By the end of the course, students will be able to
Course learning outcomes
- State what is upstream processing and how it plays a role in the development and production
- Identify and produce the different cell expression systems, their strength and weaknesses
- List and identify the main reasons for specific cell media strategies
- Identify the main advantages and disadvantages of reactors the different bioreactors and scaling strategies
- Compare and list the different strategies for upstream process optimisation and development
- Apply the principles of product engineering and how they affect the engineering of the process
- Describe utilise and interpret the different methods of assessing metabolic elemental balance in bioreactors
- Describe utilise and interpret the gas-liquid mass transfer of bioreactors
- Explain apply and calculate centrifugation steps in process recovery
- Explain apply and calculate homogenisation steps in process recovery
- Explain apply and calculate filtration steps in process recovery
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