Course overview
This course provides an overview of pharmaceutical engineering technology. The course introduces active pharmaceutical ingredient manufacturing, powder mixing and tableting, recombinant DNA technology and therapeutic protein manufacturing in the pharmaceutical industry. An introduction to batch process design emphasising unique requirements of pharmaceutical plants will be included.
Course learning outcomes
- Recognise the role of key operational units in pharmaceuticals manufacturing processes
- Explain the fundamental concepts of upstream and downstream processes in API production
- Apply the mathematical principles of cell culture kinetics fermentation
- Apply the principles of operation of batch, fed-batch and continuous bioreactor regimes
- Explain the principles of sterilization in setting-up culture and design of processes to avoid contamination risk
- Apply the fundamental principles for product recovery
- Apply the fundamental principles for filtration
- Apply the fundamental principles for primary isolation in product purification
- Apply the principles of advanced product purification by different liquid chromatography techniques
- Apply the principles of formulation to the needs of the product
- Emphasize unique requirements of modern complex pharmaceutical products
- Describe and sketch common bioseparation methods, equipment and integrated processes.
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