Course overview
An introduction to the principles and methods of medicinal chemistry including natural product and biopolymer isolation, lead generation, lead optimisation and quantitative structure-activity relationships will be presented. An introduction to the principles of biophysical chemistry will be presented, which will include techniques focused on enzyme activity and inhibition. The different classes of biologically important molecules will be introduced, including discussion on their biosynthesis. An introduction to metalloprotein and bioinorganic chemistry will be presented, including discussion of the structure and function of metalloenzymes and metalloproteins.
Course learning outcomes
- Describe the underlying principles of chemical equilibrium, thermodynamics and kinetics in the context of biological systems, and be able to clearly communicate the link between these quantitative means of characterising biochemical reactions
- describe the underlying principles of medicinal chemistry
- Develop syntheses of relevant medicinal agents
- Describe the chemistry of metalloenzymes and metalloproteins
- Provide a broad description of biologically important molecules and have a firm understanding of the chemistry and reactivity of these molecules
- Design, conduct, analyse and interpret results of an experiment, and effectively communicate these in written reports
Degree list
The following degrees include this course