Course overview
This course aims to extend the discussions of protein structure and function presented in the Biochemistry Level II courses and to use this knowledge to gain an understanding of some of the essential processes of molecular biology. The course covers two principle themes: Protein Structure and Function: topics include - structure and function of different classes of proteins, protein folding, targeted protein degradation, the development of new therapies, molecular interactions and recognition. The Control of Gene Expression: topics include; genetic circuits and synthetic biology; chromatin structure and its remodelling during transcription; the recruitment and assembly of transcription factors and the RNA polymerase complex on a gene promoter; artificially manipulating gene expression with the use of "designer genes" and synthetic transcription factors; eukaryote mRNA synthesis, processing, modification, stability and translation, and manipulation of these processes to effect selective gene expression. This course combines lectures and tutorials with cutting edge research-based practical exercises to complement the lecture material.
Course learning outcomes
- Understand aspects of protein structure and function including protein folding, degradation, development of new therapies, molecular interactions and recognition.
- Understand aspects of the control of gene expression including genetic circuits, chromatin structure and remodelling, gene promoter assembly, eukaryotic mRNA synthesis, processing and translation.
- Understand key experimental processes required to evaluate protein structure, function and gene expression, and knowledge of how to apply them to solve specific biochemical problems.
- Acquire specific skills in planning, performing, interpreting, quantitatively analysing and communicating biochemical research using a variety of modern experimental techniques.
- Find, read, interpret and critically analyse relevant scientific literature.
- Work in teams and communicate scientific outcomes.