Adelaide Centre for Epigenetics

Unravelling the epigenetic mechanisms, driving innovation and fostering collaborations.

The Adelaide Centre for Epigenetics (ACE) explores how cells develop and function, uncovering the genetic switches that impact health and disease. By collaborating widely, we turn discoveries into real-world solutions.

Founded in 2021 by Professor Jose Polo, we strive to be at the forefront of epigenetics research, with a specific focus on development, cancer and cell fate. Our team includes world renowned researchers, using cutting edge techniques including single cell and spatial omics.

Our mission is not just to understand the complex tapestry of epigenetics in cell fate but to leverage this knowledge in ways that promote health, prevent disease, and illuminate the path for future medical breakthroughs through collaborative and innovative research.

Explore our research

Our research focuses on understanding how gene activity influences cell development and disease, aiming to transform health through innovative, collaborative epigenetic research.

Engage with us

Collaborate with ACE researchers, participate in studies, or support our work to advance epigenetic discoveries and improve health outcomes.

Explore the Adelaide Centre for Epigenetics

Research capabilities Research capabilities
Research impact Research impact
Our people Our people
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Our research capabilities encompass a wide array of epigenetic disciplines, including:

Molecular epigenetics

Investigating how gene regulation is controlled during development and its implications in diseases like cancer.

Single cell & spatial omics

Utilising advanced techniques to study gene expression at the single-cell level, providing insights into cellular diversity and function.

Epigenetics in diabetes

Exploring how epigenetic modifications contribute to the development and progression of diabetes.

Clinical epigenetics

Applying epigenetic knowledge to understand and treat diseases affecting the head, neck, and airway regions.

Epigenetics & reprogramming

Examining how cells can be reprogrammed to a pluripotent state, with potential applications in regenerative medicine.

Development & epigenetics

Studying how gene enhancer activity influences cell identity and behaviour during development.

Epigenetics & gene regulation

Focusing on the role of chromatin-modifying complexes in gene expression and their dysregulation in diseases.

These capabilities are supported by cutting-edge technologies and a collaborative environment that fosters innovation and excellence in epigenetic research.

ACE brings together world-class expertise in stem cell biology, developmental epigenetics, chromatin biology, clinical epigenetics, and translational medicine into a dynamic and research-intensive centre. Our mission is to advance fundamental understanding of epigenetic regulation and translate discoveries into clinical and commercial outcomes.

By uncovering the molecular mechanisms that govern gene expression, we contribute to the development of targeted therapies and personalised medicine approaches.

ACE has received funding to explore the role of epigenetics in several diseases such as rare neurodevelopmental disorders, placenta development and diabetes. We have also contributed to local and national research policy.

In the clinical realm, our research in epigenetics has led to advancements in precision diagnostics and treatments for diseases affecting the head, neck, and airway regions. By integrating molecular and cellular technologies with clinical trials, we are at the forefront of developing personalised treatment strategies that improve patient outcomes.

Through our innovative research and collaborative efforts, we are making significant strides in understanding and addressing complex diseases, ultimately aiming to improve health outcomes globally.

Professor Jose Polo

Director of Adelaide Centre for Epigenetics
Lead: Epigenetic processes in pluripotency, reprograming & cancer
Email: jose.polo@adelaide.edu.au

Dr Adrienne Sullivan - Lead: Development & epigenetics
Dr Luke Isbel - Lead: Molecular epigenetics
Dr Qi Zhang - Lead: Epigenetics and gene regulation
Professor Harshita Pant - Lead: Otolaryngology, Head & Neck Surgery Clinical Epigenetics
Professor Robin Hobbs - Lead: Germline Stem Cell Biology Laboratory
Dr Lisa Marie Nicholas - Lead: Epigenetics in Diabetes

Collaboration plays a pivotal role in advancing cutting-edge research, enhancing the calibre, scope, and influence of research results, and elevating the chances of groundbreaking innovations.

We actively participate in collaborative efforts, locally, nationally and internationally.